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在严重骨关节炎和内翻畸形患者中,行胫骨高位截骨术、前交叉韧带重建和软骨表面置换术可获得优异的长期疗效。

Excellent long-term results in combined high tibial osteotomy, anterior cruciate ligament reconstruction and chondral resurfacing in patients with severe osteoarthritis and varus alignment.

机构信息

Centre for Sports Orthopedics and Special Joint Surgery, Orthopedic Hospital Markgroeningen, Kurt-Lindemann-Weg 10, 71706, Markgroeningen, Germany.

Department of Orthopedics and Traumatology, Paracelsus Medical Private University, Clinic Nuremberg, Nuremberg, Germany.

出版信息

Knee Surg Sports Traumatol Arthrosc. 2020 Apr;28(4):1085-1091. doi: 10.1007/s00167-019-05671-4. Epub 2019 Aug 19.

Abstract

PURPOSE

To determine survivorship and functional results of medial open-wedge high tibial osteotomy (HTO) combined with anterior cruciate ligament reconstruction (ACLR) and a chondral resurfacing (CR) procedure (abrasion/microfracture) in patients with Kellgren-Lawrence grade 3 and 4 osteoarthritis with full thickness-cartilage defects, ACL-insufficiency and varus alignment.

METHODS

A cohort of 23 patients undergoing a combined procedure of HTO (fixation with angular stable internal fixator, Tomofix), ACLR and CR for the treatment of severe symptomatic medial osteoarthritis, ACL insufficiency and varus alignment (> 4°) between 2005 and 2009 was prospectively surveyed with a minimum follow-up of 10 years with regard to survival (not requiring arthroplasty), functional outcome (subjective IKDC score), pain level (numeric rating scale), Oxford Knee Score (OKS) and subjective satisfaction. The Wilcoxon signed-rank-test was used for statistical evaluation of non-parametric data in these related samples.

RESULTS

Twenty-one cases were included, one case with incomplete follow-up data and another case excluded. The follow-up rate was 91% at 12.0 ± 1.0 years (10.0-13.4). Mean age at time of surgery was 47.3 ± 5.9 years (37.8-57.7). At final follow-up, no arthroplasty was performed in any of the cases (survival: 100%). Subjective IKDC score improved from 47 ± 11 to 75 ± 15 at 1, 72 ± 15 at 3, 73 ± 17 at 6 years and 70 ± 16 at final follow-up (p < 0.001), respectively. At final follow-up the OKS was 40 ± 7 (17-48) and pain-level significantly decreased from 7.5 ± 1.0 preoperatively to 2.9 ± 2.3 (p < 0.001) at final follow-up. All patients were satisfied with the result and stated that they would retrospectively undergo the procedure again.

CONCLUSION

A combined approach of HTO, ACLR and a CR shows excellent results in a long-term follow-up in selected young patients even in severe osteoarthritis. However, the role and potential benefit of the ACLR and CR compared to HTO alone remains unclear.

LEVEL OF EVIDENCE

Therapeutic case series, Level IV.

摘要

目的

确定合并内侧开放式楔形胫骨高位截骨术(HTO)、前交叉韧带重建术(ACLR)和软骨表面重建术(打磨/微骨折)治疗 K-L 分级 3 级和 4 级伴全层软骨缺损、ACL 功能不全和内翻畸形的患者的生存率和功能结果。

方法

前瞻性调查了 2005 年至 2009 年间接受 HTO(采用角度稳定内固定器,Tomofix 固定)、ACLR 和 CR 联合治疗严重症状性内侧骨关节炎、ACL 功能不全和内翻畸形(>4°)的 23 例患者。在 10 年以上的最低随访中,评估了生存率(无需关节置换)、功能结果(主观 IKDC 评分)、疼痛程度(数字评分量表)、牛津膝关节评分(OKS)和主观满意度。采用 Wilcoxon 符号秩检验对相关样本的非参数数据进行统计学评估。

结果

21 例患者纳入研究,1 例患者随访资料不完整,1 例患者被排除。随访率为 91%,随访时间为 12.0±1.0 年(10.0-13.4 年)。手术时的平均年龄为 47.3±5.9 岁(37.8-57.7 岁)。末次随访时,所有患者均未行关节置换(生存率:100%)。主观 IKDC 评分分别从术前的 47±11 分提高到 1 年时的 75±15 分、3 年时的 72±15 分、6 年时的 73±17 分和末次随访时的 70±16 分(p<0.001)。末次随访时,OKS 为 40±7(17-48),疼痛评分从术前的 7.5±1.0 显著降低至 2.9±2.3(p<0.001)。所有患者对结果均满意,并表示会回顾性再次接受该手术。

结论

对于选择的年轻患者,HTO、ACLR 和软骨表面重建术的联合治疗在长期随访中具有良好的效果,即使在严重的骨关节炎中也是如此。然而,ACL 重建术和软骨表面重建术与单独 HTO 相比的作用和潜在益处尚不清楚。

证据水平

治疗性病例系列,IV 级。

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