重症肌无力和伊顿-兰伯特综合征的联合特征：血清中的抗神经节苷脂抗体
Combined features of myasthenia gravis and Eaton-Lambert syndrome: anti-ganglioside antibodies in serum.
作者信息
Kusunoki S, Tsuji S, Inoue K, Mannen T, Nagai Y
机构信息
Department of Neurology, University of Tokyo, Japan.
出版信息
J Neurol Sci. 1988 Oct;87(1):61-6. doi: 10.1016/0022-510x(88)90054-8.
PMID:3142966
Abstract
We studied 2 patients with Eaton-Lambert syndrome showing some features of myasthenia gravis. Among 9 different glycolipid antigens examined, serum titers of IgG antibodies to GT1b, GD1a, and sialylparagloboside were increased. Those antibodies may be involved in the pathogenesis of the presynaptic neuromuscular block that was presumed to be present in these patients.
摘要
我们研究了2例具有重症肌无力某些特征的伊顿-兰伯特综合征患者。在检测的9种不同糖脂抗原中，抗GT1b、GD1a和唾液酸化副球蛋白的IgG抗体血清滴度升高。这些抗体可能参与了推测存在于这些患者中的突触前神经肌肉阻滞的发病机制。
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