Knisely A S, Leal S M, Singer D B
Program in Developmental Pathology, Brown University, Providence, RI.
J Pediatr. 1988 Dec;113(6):1074-7. doi: 10.1016/s0022-3476(88)80585-7.
Several infants and neonates who had received long-term ventilatory assistance had subnormal diaphragmatic muscle mass on gross necropsy examination. We conducted a retrospective study of our hospital infant necropsy files to determine whether prolonged ventilatory support was associated with diminution in myofiber cross-sectional area selectively affecting the diaphragm. We found that long-term ventilatory assistance may predispose diaphragmatic myofibers to disuse atrophy or to failure or normal growth. This phenomenon may contribute to difficulties in weaning infants from ventilatory support.
几名接受长期通气支持的婴儿和新生儿在大体尸检时膈肌肌肉质量低于正常水平。我们对本院婴儿尸检档案进行了一项回顾性研究，以确定长时间的通气支持是否与选择性影响膈肌的肌纤维横截面积减小有关。我们发现，长期通气支持可能使膈肌肌纤维易于出现废用性萎缩，或无法正常生长。这种现象可能导致婴儿撤机困难。
