氢氧化铝对双氟尼酸吸收的影响。
Effect of aluminum hydroxide on diflunisal absorption.
作者信息
Verbeeck R, Tjandramaga T B, Mullie A, Verbesselt R, de Schepper P J
出版信息
Br J Clin Pharmacol. 1979 May;7(5):519-22. doi: 10.1111/j.1365-2125.1979.tb00997.x.
Abstract
1 The effect of aluminum hydroxide on the oral absorption of diflunisal was studied in healthy subjects. 2 Relative bioavailability of the oral diflunisal dose (500 mg) was estimated by comparison of the areas under plasma concentration versus time curves, and comparison of the amount of drug (unchanged + glucuronides) excreted in the urine. 3 From the AUC-method, a relative bioavailability of 0.60 was calculated. A similar value (F = 0.63) was obtained from the urinary excretion data. 4 The results indicate that co-administration of aluminum hydroxide reduces the bioavailability of oral diflusinal by about 40%.
摘要
1 在健康受试者中研究了氢氧化铝对双氯芬酸口服吸收的影响。2 通过比较血浆浓度-时间曲线下的面积以及比较尿中排泄的药物（原形+葡糖醛酸苷）量，估算了口服双氯芬酸剂量（500毫克）的相对生物利用度。3 根据AUC法计算出相对生物利用度为0.60。从尿排泄数据获得了类似的值（F = 0.63）。4 结果表明，氢氧化铝的共同给药使口服双氯芬酸的生物利用度降低了约40%。
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