Bonelli J, Hruby K, Magometschnigg D, Hitzenberger G, Kaik G
Int J Clin Pharmacol Biopharm. 1977 Jul;15(7):337-9.
The bio-availability of Novodigal (beta-acetyldigoxine) alone and applied together with Alucol (aluminum hydroxide, magnesium hydroxide) was studied in six healthy probands. Bio-availability parameters were calculated from the areas under the plasma concentration curves and from the comparison of the blood levels after absorption during steady state. There was no significant difference between the bio-availability of beta-acetyldigoxine alone and that of the combination with Alucol. Thus, beta-acetyldigoxine combined with antacids of the aluminum hydroxide and magnesium hydroxide type can be applied in the same dosage as usual since no decrease of effect has to be apprehended.
在6名健康受试者中研究了诺伏地高辛（β-乙酰地高辛）单独使用以及与阿路可（氢氧化铝、氢氧化镁）联合使用时的生物利用度。生物利用度参数根据血浆浓度曲线下面积以及稳态吸收后血药浓度的比较来计算。β-乙酰地高辛单独使用时的生物利用度与和阿路可联合使用时的生物利用度之间没有显著差异。因此，β-乙酰地高辛与氢氧化铝和氢氧化镁类型的抗酸剂联合使用时可以按照常规剂量使用，因为无需担心药效降低。
