正常抗血友病因子（因子VIII）是否存在一种前体形式，其相对无促凝血活性？ - Suppr | 超能文献

Is there a precursive, relatively procoagulant-inactive form of normal antihemophilic factor (factor VIII)?

作者信息

Switzer M E, Pizzo S V, McKee P A

出版信息

Blood. 1979 Oct;54(4):916-27.

Abstract

摘要

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Is there a precursive, relatively procoagulant-inactive form of normal antihemophilic factor (factor VIII)?正常抗血友病因子（因子VIII）是否存在一种前体形式，其相对无促凝血活性？

Blood. 1979 Oct;54(4):916-27.

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Studies on human antihemophilic factor. Evidence for a covalently linked subunit structure.人类抗血友病因子的研究。共价连接亚基结构的证据。

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Molecular structural studies of human factor VIII.人凝血因子VIII的分子结构研究

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Characterization of proteases in AHF concentrates: effect on factor VIII:von Willebrand protein as assessed by high-pressure gel permeation chromatography.抗血友病因子浓缩物中蛋白酶的特性：通过高压凝胶渗透色谱法评估对凝血因子VIII：血管性血友病因子的影响。

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Two distinct forms of Factor VIII coagulant protein in human plasma. Cleavage by thrombin, and differences in coagulant activity and association with von Willebrand factor.人血浆中凝血因子 VIII 凝血蛋白的两种不同形式。凝血酶切割作用、凝血活性差异以及与血管性血友病因子的关联

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Partial purification of biologically active, low molecular weight, human antihemophilic factor free of Von Willebrand factor. I. Partial characterization and evidence for disulfide bond(s) susceptible to limited reduction.不含血管性血友病因子的具有生物活性的低分子量人抗血友病因子的部分纯化。I. 部分特性鉴定及对有限还原敏感的二硫键的证据

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Enhanced yield of antihemophilic factor and von Willebrand factor by cryoprecipitation with polyethylene glycol.

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Porcine factor VIII:C prepared by affinity interaction with von Willebrand factor and heterologous antibodies: sodium dodecyl sulfate polyacrylamide gel analysis.通过与血管性血友病因子和异源抗体进行亲和相互作用制备的猪凝血因子VIII：C：十二烷基硫酸钠聚丙烯酰胺凝胶分析

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Degradation of purified factor VIII by endogenous contaminating enzymes.纯化的凝血因子VIII被内源性污染酶降解。

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Von Willebrand factor: dissociation from antihemophilic factor procoagulant activity.血管性血友病因子：与抗血友病因子促凝活性的解离

Science. 1973 Dec 14;182(4117):1149-51. doi: 10.1126/science.182.4117.1149.

引用本文的文献

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Role of human factor VIII in factor X activation.人凝血因子VIII在凝血因子X激活中的作用。

J Clin Invest. 1982 Apr;69(4):950-8. doi: 10.1172/jci110534.

2

Analysis of factor VIII coagulant antigen in normal, thrombin-treated, and hemophilic plasma.正常血浆、凝血酶处理血浆和血友病血浆中凝血因子 VIII 促凝抗原分析。

Proc Natl Acad Sci U S A. 1981 Aug;78(8):5137-41. doi: 10.1073/pnas.78.8.5137.

3

Two distinct forms of Factor VIII coagulant protein in human plasma. Cleavage by thrombin, and differences in coagulant activity and association with von Willebrand factor.人血浆中凝血因子 VIII 凝血蛋白的两种不同形式。凝血酶切割作用、凝血活性差异以及与血管性血友病因子的关联

J Clin Invest. 1984 Feb;73(2):307-16. doi: 10.1172/JCI111215.