一项比较 Mepitel® Film 与标准护理预防局部晚期头颈部鳞状细胞癌（SCCHN）放疗患者放射性皮炎的随机试验（RAREST-01）。
A randomized trial (RAREST-01) comparing Mepitel® Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN).
机构信息
Department of Radiation Oncology, University of Luebeck, Germany.
Department of Radiation Oncology, University of Luebeck, Germany.
出版信息
Radiother Oncol. 2019 Oct;139:79-82. doi: 10.1016/j.radonc.2019.07.023. Epub 2019 Aug 17.
PMID:31431372
Abstract
Mepitel® Film (MEP) and standard care (STD) were compared for radiation dermatitis in SCCHN patients. This trial was stopped prematurely since13/28 patients did not tolerate MEP. Grade ≥2 dermatitis: 34.8% (MEP) vs. 35.7% (STD) at 50 Gy, 65.2% vs. 59.3% at 60 Gy. MEP was unsatisfactorily tolerated and appeared not superior (NCT03047174).
摘要
Mepitel® Film（MEP）与标准护理（STD）在头颈部鳞癌（SCCHN）患者中治疗放射性皮炎的效果进行了比较。由于 28 名患者中有 13 名不能耐受 MEP，该试验提前终止。在 50Gy 时，≥2 级皮炎发生率为 34.8%（MEP）与 35.7%（STD），在 60Gy 时为 65.2%与 59.3%。MEP 耐受性差，且疗效不优（NCT03047174）。
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