通过一维 AlO 纳米结构控制成纤维细胞黏附和增殖。
Controlling fibroblast adhesion and proliferation by 1D AlO nanostructures.
机构信息
Department of Paediatric Cardiology, Saarland University, 66421 Homburg, Germany.
Department of Trauma, Hand and Reconstructive Surgery, Saarland University, 66421 Homburg, Germany.
出版信息
IET Nanobiotechnol. 2019 Aug;13(6):621-625. doi: 10.1049/iet-nbt.2018.5088.
The fibrotic encapsulation, which is mainly accompanied by an excessive proliferation of fibroblasts, is an undesired phenomenon after the implantation of various medical devices. Beside the surface chemistry, the topography plays also a major role in the fibroblast-surface interaction. In the present study, one-dimensional aluminium oxide (1D AlO) nanostructures with different distribution densities were prepared to reveal the response of human fibroblasts to the surface topography. The cell size, the cell number and the ability to form well-defined actin fibres and focal adhesions were significantly impaired with increasing distribution density of the 1D AlO nanostructures on the substratum.
纤维包裹，主要伴随着成纤维细胞的过度增殖，是各种医疗器械植入后的一种不良现象。除了表面化学性质，形貌在成纤维细胞与表面的相互作用中也起着主要作用。在本研究中，制备了具有不同分布密度的一维氧化铝（1D AlO）纳米结构，以揭示人成纤维细胞对表面形貌的响应。随着基底上 1D AlO 纳米结构分布密度的增加，细胞大小、细胞数量以及形成明确的肌动蛋白纤维和粘着斑的能力显著受损。
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