高剂量甲氨蝶呤治疗恶性黑色素瘤。
High-dose methotrexate in malignant melanoma.
作者信息
Karakousis C P, Carlson M
出版信息
Cancer Treat Rep. 1979 Aug;63(8):1405-7.
PMID:314335
Abstract
High-dose methotrexate was given to 28 patients with advanced malignant melanoma who had previously failed to respond to two chemotherapy protocols. There were five instances of serious, but not fatal, toxicity. One patient has had an objective response and seven patients have had stabilization of disease with an average duration of 4 months.
摘要
对28例先前对两种化疗方案均无反应的晚期恶性黑色素瘤患者给予大剂量甲氨蝶呤治疗。出现了5例严重但非致命的毒性反应。1例患者有客观反应，7例患者病情稳定，平均持续时间为4个月。
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