Neuroscience Division of the Biomedical and Health Sciences Institute, University of Georgia, 310 E Campus Road, Athens, GA, 30602, USA.
Psychology Department, University of Georgia, 125 Baldwin Street, Athens, GA, 30602, USA; Dionnet L. Bhatti is now in the Laboratory of Molecular and Cellular Neuroscience at The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.
Behav Brain Res. 2019 Dec 16;375:112160. doi: 10.1016/j.bbr.2019.112160. Epub 2019 Aug 18.
The neuropeptide galanin is a potential therapeutic target for treating stress-related disorders, such as post-traumatic stress disorder (PTSD); however, its effects on contextual fear conditioning (CFC), an accepted animal model of PTSD, are not well understood. Dysregulation of the medial prefrontal cortex (mPFC) is implicated in PTSD. We investigated the effects of galanin (1 ug) administrated bilaterally into the prelimbic cortex, a division of the mPFC, on the consolidation, expression, and extinction of CFC of male Sprague-Dawley rats. Galanin administration significantly reduced consolidation and expression of CFC, but had no effect on retention or retrieval of extinction learning. These data further implicate galanin as a potential therapeutic target for treating stress-related disorders, particularly those characterized by aberrant emotional memory.
神经肽甘丙肽是治疗应激相关疾病（如创伤后应激障碍（PTSD））的潜在治疗靶点；然而，其对情境恐惧条件反射（CFC）的影响，即 PTSD 的一种公认的动物模型，尚未得到充分理解。内侧前额叶皮层（mPFC）的失调与 PTSD 有关。我们研究了双侧注入 mPFC 一个分支——前额叶皮层的甘丙肽（1ug）对雄性 Sprague-Dawley 大鼠 CFC 的巩固、表达和消退的影响。甘丙肽给药显著降低了 CFC 的巩固和表达，但对保留或检索消退学习没有影响。这些数据进一步表明甘丙肽可能是治疗应激相关疾病的潜在治疗靶点，特别是那些以异常情绪记忆为特征的疾病。
