Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna-son, Okinawa 904-0495, Japan.
Cells. 2019 Aug 20;8(8):939. doi: 10.3390/cells8080939.
Foxp3-expressing regulatory T (Treg) cells can suppress the activity of various types of immune cells and play key roles in the maintenance of self-tolerance and in the regulation of immune responses against pathogens and tumor cells. Treg cells consist of heterogeneous subsets that have distinct phenotypes and functions. Upon antigen stimulation, naïve-like thymus-derived Treg cells, which circulate in secondary lymphoid organs, can differentiate into effector Treg (eTreg) cells and migrate to and control immune homeostasis of peripheral tissues. eTreg cells are heterogeneous in terms of their ability to localize to specific tissues and suppress particular types of immune responses. Differentiation and function of diverse eTreg subsets are regulated by a variety of transcription factors that are activated by antigens and cytokines. In this article, we review the current understanding of the transcriptional regulation of differentiation and function of eTreg cells.
Foxp3 表达的调节性 T（Treg）细胞可以抑制各种类型免疫细胞的活性，并在维持自身耐受和调节针对病原体和肿瘤细胞的免疫反应中发挥关键作用。Treg 细胞由具有不同表型和功能的异质性亚群组成。在抗原刺激下，循环于次级淋巴器官中的初始样胸腺来源的 Treg 细胞可分化为效应性 Treg（eTreg）细胞，并迁移至外周组织，控制免疫稳态。eTreg 细胞在定位于特定组织和抑制特定类型免疫反应的能力方面存在异质性。不同 eTreg 亚群的分化和功能受多种转录因子的调控，这些转录因子被抗原和细胞因子激活。本文综述了 eTreg 细胞分化和功能的转录调控的最新研究进展。
