Futagami Seiji, Yamawaki Hiroshi, Agawa Shuhei, Ikeda Go, Noda Hiroto, Kirita Kumiko, Higuchi Kazutoshi, Gudis Katya, Murakami Makoto, Kodaka Yasuhiro, Ueki Nobue, Iwakiri Katsuhiko
Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School.
J Nippon Med Sch. 2020 Mar 11;87(1):2-6. doi: 10.1272/jnms.JNMS.2020_87-101. Epub 2019 Aug 20.
Functional dyspepsia (FD) is a common disease that can markedly impair quality of life. In the 2016 Rome IV criteria, a diagnosis of FD requires the presence of bothersome FD symptoms. In 2009, a new diagnosis, early chronic pancreatitis (ECP), was proposed as a means to facilitate early treatment of chronic pancreatitis and prevent progression to chronic pancreatitis. Although chronic pancreatitis was reported to be a cause of dyspepsia, data on the relation between ECP and FD patients are limited. We therefore investigated differences between ECP patients and FD patients in the percentages of those with severe epigastric pain, early satiety, and postprandial abdominal fullness. Several studies reported an association between the cause of chronic pancreatitis and endosonographic features. In addition, endosonography was useful for distinguishing ECP patients from FD patients with pancreatic enzyme abnormalities. Thus, we compared endosonographic characteristics in these patient groups. Future studies should attempt to determine why selected FD patients with pancreatic enzyme abnormalities develop ECP.
功能性消化不良（FD）是一种常见疾病，会显著损害生活质量。在2016年罗马IV标准中，FD的诊断需要存在令人烦恼的FD症状。2009年，一种新的诊断——早期慢性胰腺炎（ECP）被提出，作为促进慢性胰腺炎早期治疗和预防进展为慢性胰腺炎的一种方法。尽管据报道慢性胰腺炎是消化不良的一个原因，但关于ECP与FD患者之间关系的数据有限。因此，我们调查了ECP患者和FD患者在严重上腹痛、早饱及餐后腹部胀满患者百分比方面的差异。几项研究报告了慢性胰腺炎的病因与内镜超声特征之间的关联。此外，内镜超声有助于将ECP患者与有胰腺酶异常的FD患者区分开来。因此，我们比较了这些患者组的内镜超声特征。未来的研究应尝试确定为什么某些有胰腺酶异常的FD患者会发展为ECP。
