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稽留流产患者母体甲基四氢叶酸还原酶基因突变

Maternal methyltetrahydrofolate reductase gene mutation in patients with missed abortions.

作者信息

Rady Helmy A

机构信息

Obst. & Gyn. Department, Faculty of Medicine, University of Alexandria, Alexandria, Egypt.

出版信息

J Taibah Univ Med Sci. 2017 Jul 14;13(1):93-96. doi: 10.1016/j.jtumed.2017.04.004. eCollection 2018 Feb.

DOI:10.1016/j.jtumed.2017.04.004
PMID:31435309
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6695003/
Abstract

BACKGROUND

Missed abortions are a common problem, often caused by thrombophilia in both recurring and non-recurring cases.

AIM

To determine whether the presence of a mutation in the methyltetrahydrofolate reductase () gene correlates with missed abortions.

PATIENTS AND METHODS

We selected two hundred patients for this study in two groups: the study group, which consisted of one hundred patients with a history of missed abortion; and the control group, which consisted of one hundred patients with no history of missed abortion.

RESULTS

Of the 200 patients, mutations in were only found in forty-four patients-thirty-four from the study group and ten from the control group.

CONCLUSIONS

gene mutation is a common cause of both recurring and non-recurring missed abortions.

摘要

背景

稽留流产是一个常见问题，在复发性和非复发性病例中通常由血栓形成倾向引起。

目的

确定亚甲基四氢叶酸还原酶（）基因突变的存在是否与稽留流产相关。

患者与方法

我们将200名患者分为两组进行本研究：研究组，由100名有稽留流产病史的患者组成；对照组，由100名无稽留流产病史的患者组成。

结果

在200名患者中，仅在44名患者中发现了突变——研究组34名，对照组10名。

结论

基因突变是复发性和非复发性稽留流产的常见原因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/880d/6695003/f62ed658a6e7/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/880d/6695003/f62ed658a6e7/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/880d/6695003/f62ed658a6e7/gr1.jpg

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本文引用的文献

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Genet Mol Res. 2015 Jul 28;14(3):8500-8. doi: 10.4238/2015.July.28.19.
2
Multiple Inherited Thrombophilic Gene Polymorphisms in Spontaneous Abortions in Turkish Population.土耳其人群自然流产中多种遗传性血栓形成倾向基因多态性
Int J Mol Cell Med. 2015 Spring;4(2):120-7.
3
Metabolism and gene polymorphisms of the folate pathway in Brazilian women with history of recurrent abortion.
Rev Bras Ginecol Obstet. 2015 Feb;37(2):71-6. doi: 10.1590/SO100-720320140005223. Epub 2015 Feb 1.
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Association between thrombophilia and the post-thrombotic syndrome: a systematic review and meta-analysis.血栓形成倾向与血栓后综合征的关系：系统评价和荟萃分析。
J Thromb Haemost. 2014 Jan;12(1):14-23. doi: 10.1111/jth.12447.
5
Cognitive behavior therapy for psychological distress in patients with recurrent miscarriage.认知行为疗法治疗复发性流产患者的心理困扰。
Psychol Res Behav Manag. 2013 Jul 19;6:37-43. doi: 10.2147/PRBM.S44327. Print 2013.
6
MTHFR C677T polymorphism, folate, vitamin B12 and homocysteine in recurrent pregnancy losses: a case control study among North Indian women.亚甲基四氢叶酸还原酶 C677T 多态性、叶酸、维生素 B12 和同型半胱氨酸与复发性流产的关系：一项在印度北部妇女中进行的病例对照研究。
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