Rosskamp R, Haverkamp F
Zentrum für Kinderheilkunde Universität, Bonn, Federal Republic of Germany.
Eur J Pediatr. 1988 Oct;148(1):17-8. doi: 10.1007/BF00441805.
Growth hormone releasing hormone (GHRH)-testing was performed in 24 short normal children (16 male, 8 female). Before and after administration of GHRH1-44 (1 microgram/kg body weight i.v.) blood samples for growth hormone (GH) determination were drawn at -30, 0, 1, 2, 3, 4, 6, 8, 10, 15, 30, 45, 60, and 90 min. Plasma GH increase was apparent 1 min after injection and in 12 patients (7 female) peak plasma GH values were reached within 15 min. In all patients plasma GH levels were greater than 10 ng/ml within the first 8 min following GHRH injection, but in 4 patients this level was not attained when considering only GH values obtained after 15 min. These results demonstrate the capability of the pituitary to rapidly secrete GH in response to GHRH1-44 in children. Therefore, in this age group blood samples for GH determination should be taken earlier when testing with GHRH1-44.
对24名身材矮小但发育正常的儿童（16名男性，8名女性）进行了生长激素释放激素（GHRH）检测。静脉注射GHRH1-44（1微克/千克体重）之前和之后，分别在-30、0、1、2、3、4、6、8、10、15、30、45、60和90分钟采集血样以测定生长激素（GH）。注射后1分钟血浆GH明显升高，12名患者（7名女性）在15分钟内达到血浆GH峰值。在所有患者中，注射GHRH后的前8分钟内血浆GH水平均大于10纳克/毫升，但在4名患者中，仅考虑15分钟后获得的GH值时未达到该水平。这些结果表明儿童垂体对GHRH1-44有快速分泌GH的能力。因此，在该年龄组使用GHRH1-44进行检测时，应更早采集血样以测定GH。
