Neuvonen P J, Lehtovaara R, Bardy A, Elomaa E
Eur J Clin Pharmacol. 1979 May 21;15(4):263-8. doi: 10.1007/BF00618515.
The effect of administration for three days of acetylsalicylic acid (1500 mg/day), phenylbutazone (300 mg/day), paracetamol (1500 mg/day) and tolfenamic acid (300 mg/day) on serum concentrations of phenytoin and carbamazepine were studied in a group of patients on continuous antiepileptic therapy. When measured 10 h after the last dose of the analgesics, the only significant effect was a decrease in total serum phenytoin after three days of phenylbutazone. When six patients on continuous phenytoin therapy took phenylbutazone for two weeks there was at two days an initial decrease, followed by a signficiant increase in total serum phenytoin and a concomitant increase in free phenytoin in serum. Even phenylbutazone was well tolerated by most of the patients. However, its use had to be discontinued on one patient due to obvious signs of phenytoin intoxication, with concomitant increases in the serum free and total phenytoin concentrations.
在一组持续接受抗癫痫治疗的患者中，研究了连续三天给予乙酰水杨酸（1500毫克/天）、保泰松（300毫克/天）、对乙酰氨基酚（1500毫克/天）和托芬那酸（300毫克/天）对苯妥英和卡马西平血清浓度的影响。在最后一剂镇痛药服用10小时后进行测量时，唯一显著的影响是保泰松服用三天后血清总苯妥英水平降低。当6名持续接受苯妥英治疗的患者服用保泰松两周时，血清总苯妥英在两天时出现初始下降，随后显著升高，同时血清中游离苯妥英也增加。大多数患者对保泰松耐受性良好。然而，有一名患者因出现明显的苯妥英中毒迹象，同时血清游离和总苯妥英浓度升高，不得不停用保泰松。
