Shadduck R K, Winkelstein A, Zeigler Z, Lichter J, Goldstein M, Michaels M, Rabin B
Exp Hematol. 1979 May;7(5):264-71.
A 17-year-old female developed severe aplastic anemia following serologically proven infectious mononucleosis. In vitro studies, using the granulocyte colony forming technique, suggested that the aplasia may have resulted from an immune mechanism. The patient's marrow grew no granulocyte colonies and caused inhibition of colony formation when mixed with normal marrows. The patient recovered fully after therapy with antithymocyte globulin and marrow cultures showed disappearance of the inhibitory effect. These observations suggest that the severe aplasia may have resulted from an aberrant immune response which followed infection by EB virus.
一名17岁女性在血清学确诊为传染性单核细胞增多症后发生了严重再生障碍性贫血。采用粒细胞集落形成技术进行的体外研究表明，再生障碍可能是由免疫机制导致的。该患者的骨髓未生长出粒细胞集落，且与正常骨髓混合时会抑制集落形成。患者在接受抗胸腺细胞球蛋白治疗后完全康复，骨髓培养显示抑制作用消失。这些观察结果表明，严重再生障碍可能是由EB病毒感染后异常的免疫反应所致。
