Lazarus K H, Baehner R L
Pediatrics. 1981 Jun;67(6):907-10.
A 12 1/2-year-old white girl developed pancytopenia and severe aplastic anemia three weeks following symptoms of infectious mononucleosis. Pancytopenia complicating infectious mononucleosis has been reported in only nine previous cases and only three were proven to have aplastic anemia. The mean time from onset of symptoms of infectious mononucleosis to the nadir of pancytopenia was 21.3 days with a range of seven to 49 days. Two patients died from complications of the pancytopenia. In those patients who recovered, the mean time from diagnosis of the pancytopenia to recovery of bone marrow function was 6.25 days with a range of four to eight days. In contrast to other causes of aplastic anemia, return of normal platelet levels coincided with recovery from pancytopenia. The etiology of the pancytopenia and aplastic anemia are unknown but immunologic causes are suspected because of the rapid recovery of the bone marrow and its possible responsiveness to steroids.
一名12岁半的白人女孩在出现传染性单核细胞增多症症状三周后出现全血细胞减少和严重再生障碍性贫血。传染性单核细胞增多症并发全血细胞减少此前仅报道过9例，其中仅3例被证实患有再生障碍性贫血。从传染性单核细胞增多症症状出现到全血细胞减少最低点的平均时间为21.3天，范围为7至49天。两名患者死于全血细胞减少的并发症。在康复的患者中，从全血细胞减少诊断到骨髓功能恢复的平均时间为6.25天，范围为4至8天。与再生障碍性贫血的其他病因不同，正常血小板水平的恢复与全血细胞减少的恢复同时发生。全血细胞减少和再生障碍性贫血的病因尚不清楚，但由于骨髓的快速恢复及其对类固醇的可能反应性，怀疑是免疫原因。
