Moreau J F, Donaldson D D, Bennett F, Witek-Giannotti J, Clark S C, Wong G G
Genetics Institute Inc., Cambridge, Massachusetts 02140.
Nature. 1988 Dec 15;336(6200):690-2. doi: 10.1038/336690a0.
Leukaemia inhibitory factor (LIF) is a cytokine that induces macrophage differentiation of the murine M1 myeloid leukaemia cell line. We have isolated a cDNA clone encoding a novel human haemopoietic growth factor, human interleukin for DA cells (HILDA) that supports the proliferation of the murine interleukin-3-dependent leukaemic cell line, DA-la (refs 3-5). HILDA proved to be identical to LIF. The demonstration that the differentiation factor LIF will also serve as a growth factor for at least one myeloid leukaemic cell line provides further evidence that the distinction between growth-promoting and differentiation-inducing activities are largely determined by the target cell type.
白血病抑制因子（LIF）是一种可诱导小鼠M1髓系白血病细胞系巨噬细胞分化的细胞因子。我们分离出了一个编码新型人类造血生长因子的cDNA克隆，即人类DA细胞白细胞介素（HILDA），它能支持小鼠白细胞介素-3依赖的白血病细胞系DA-la的增殖（参考文献3 - 5）。结果证明HILDA与LIF是同一物质。分化因子LIF也可作为至少一种髓系白血病细胞系的生长因子，这一发现进一步证明，促进生长和诱导分化活性之间的区别很大程度上取决于靶细胞类型。
