Department of Interventional Radiology, University Hospital Southampton, Tremona Road, Southampton, SO16 6YD, UK.
University of Southampton Medical School, 12 University Road, Southampton, SO17 1BJ, UK.
Cardiovasc Intervent Radiol. 2020 Jan;43(1):23-28. doi: 10.1007/s00270-019-02298-3. Epub 2019 Aug 22.
Many studies have looked at global changes in the International Prostate Symptom Score (IPSS) following PAE; however, no studies have examined the breakdown between storage and voiding symptoms. We aimed to explore the extent to which PAE improves storage symptoms in relation to voiding symptoms.
This single-center, prospective cohort study recruited consecutive patients undergoing PAE from June 2012 to June 2016. The IPSS breakdown was recorded pre-PAE, at 3 months and 12 months post-PAE. Planned statistical analysis included the paired t test.
A total of 43 patients were recruited (mean age 64.72 ± 6.27, prostate volume 88.65 ± 37.23 cm, IPSS 23.02 ± 5.84, QoL 4.98 ± 1.01, PSA 4.2 ± 2.8). Storage symptoms were more frequently the most severe symptom (58.1%). Voiding score (13.35-5.39, p < 0.001) and storage score (9.67-5.08, p < 0.001) both improved; however, voiding improved to a greater extent (1.9 vs. 1.5 mean per question, p = 0.023). PAE was most consistent when improving storage symptoms ('Urgency' improved in 86% patients, 'Frequency' and 'Nocturia' 77%).
Storage symptoms are a significant problem for patients with benign prostatic obstruction. PAE is an effective treatment for both storage and voiding symptoms. More research is needed to evaluate how this compares with surgical techniques.
许多研究都观察了前列腺动脉栓塞术（PAE）后国际前列腺症状评分（IPSS）的全球变化；然而，没有研究检查过储存和排尿症状的细分。我们旨在探讨 PAE 在多大程度上改善与排尿症状相关的储存症状。
这是一项单中心前瞻性队列研究，招募了 2012 年 6 月至 2016 年 6 月期间接受 PAE 的连续患者。在 PAE 前、3 个月和 12 个月后记录 IPSS 细分。计划的统计分析包括配对 t 检验。
共招募了 43 名患者（平均年龄 64.72±6.27 岁，前列腺体积 88.65±37.23cm3，IPSS23.02±5.84，QoL4.98±1.01，PSA4.2±2.8）。储存症状更常是最严重的症状（58.1%）。排尿评分（13.35-5.39，p<0.001）和储存评分（9.67-5.08，p<0.001）均有改善；然而，排尿症状改善程度更大（1.9 比每个问题平均改善 1.5，p=0.023）。PAE 在改善储存症状方面最为一致（“尿急”在 86%的患者中得到改善，“频尿”和“夜尿”在 77%的患者中得到改善）。
储存症状是良性前列腺梗阻患者的一个重大问题。PAE 是治疗储存和排尿症状的有效方法。需要进一步研究来评估其与手术技术的比较。
