Federal University of Espírito Santo, Alegre, Brazil.
Nutr Cancer. 2020;72(4):610-619. doi: 10.1080/01635581.2019.1649437. Epub 2019 Aug 23.
Antioxidants present in food can act as a protective factor against the development of colorectal cancer (CRC) by reducing the development of aberrant crypt foci (ACF). This study aimed to analyze the effects of supplementation with juçara fruit pulp on the number of ACF and the SOD1 expression in an experimental model of CRC. Colorectal carcinogenesis was induced with 1,2-dimethylhydrazine (DMH) in 16 young female rats () given a diet supplemented with either juçara fruit pulp (DMH+/juçara+) or control (DMH+/juçara-). Five animals were used as a negative control (DMH-/juçara-). The (DMH+/juçara+) group received 14 days of supplementation (100 ml/animal/day) at 2-day intervals for 1 month. The number of ACF, area of positive staining for SOD1, and SOD1 expression score were evaluated. The (DMH+/juçara+) group presented a lower number of ACF, ACF > 3 crypts, and greater SOD1 expression in the colorectal mucosa. Based on the reduction in the number of lesions and possible positive impact on antioxidant enzymes, juçara fruit pulp appears to support the prevention of CRC, opening new possibilities for its use in dietary supplementation, as well as in the development of products and medications for the prevention and treatment of CRC.
食物中的抗氧化剂可以通过减少异常隐窝病灶 (ACF) 的发展，作为预防结直肠癌 (CRC) 发展的保护因素。本研究旨在分析 Juçara 果浆补充对 CRC 实验模型中 ACF 数量和 SOD1 表达的影响。采用 1,2-二甲基肼 (DMH) 诱导 16 只年轻雌性大鼠发生结直肠癌变 ()，并给予补充 Juçara 果浆的饮食 (DMH+/juçara+) 或对照饮食 (DMH+/juçara-)。5 只动物作为阴性对照 (DMH-/juçara-)。(DMH+/juçara+) 组在 1 个月内每隔 2 天接受 14 天的补充 (100 ml/动物/天)。评估 ACF 的数量、SOD1 阳性染色面积和 SOD1 表达评分。(DMH+/juçara+) 组结直肠黏膜中的 ACF 数量较少、ACF > 3 个隐窝和 SOD1 表达较高。基于病变数量的减少和对抗氧化酶的可能积极影响，Juçara 果浆似乎支持 CRC 的预防，为其在饮食补充、产品和药物的开发以及 CRC 的预防和治疗方面的应用开辟了新的可能性。
