Cajavilca Christian E, Gadhia Rajan R, Román Gustavo C
Vascular Neurology, Houston Methodist Hospital Neurological Institute, Houston, TX 77030, USA.
Weill Cornell Medical College, Department of Neurology, Cornell University, New York, NY 10065, USA.
Brain Sci. 2019 Aug 22;9(9):211. doi: 10.3390/brainsci9090211.
The incidence of dementia is on the rise and expected to continue to increase in the foreseeable future. Two of the most common subtypes of dementia are Alzheimer's subtype and vascular dementia. Hyperhomocysteinemia has been shown to serve as a risk factor for dementia due to an associated blood-brain barrier dysfunction and subsequent small-vessel disease pathology. There are varying causes for hyperhomocysteinemia, including genetic and dietary, among others. We highlight the importance of identifying hyperhomocysteinemia as a potential etiologic and therapeutic target for the most common subtypes of dementia.
痴呆症的发病率正在上升，并且预计在可预见的未来还会继续增加。痴呆症最常见的两种亚型是阿尔茨海默病亚型和血管性痴呆。高同型半胱氨酸血症已被证明是痴呆症的一个风险因素，因为它会导致血脑屏障功能障碍以及随后的小血管疾病病理变化。高同型半胱氨酸血症有多种病因，包括遗传和饮食等。我们强调将高同型半胱氨酸血症确定为最常见痴呆症亚型的潜在病因和治疗靶点的重要性。
