The Scripps Research Institute, La Jolla, CA
Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, MA.
J Exp Med. 2019 Oct 7;216(10):2226-2228. doi: 10.1084/jem.20191099. Epub 2019 Aug 23.
Antibody neutralization of a virus in vitro is often associated with protection against viral exposure in vivo, but the mechanisms operational in vivo are often unclear. By investigating a large number of antibodies, Earnest et al. (https://doi.org/10.1084/jem.20190736) show the importance of antibody effector function in neutralizing antibody protection against an emerging alphavirus in a mouse model.
抗体在体外对病毒的中和作用通常与体内对病毒暴露的保护作用相关，但体内起作用的机制往往不清楚。Earnest 等人通过研究大量抗体（https://doi.org/10.1084/jem.20190736），在小鼠模型中表明了抗体效应功能在中和抗体对抗新兴甲病毒中的重要性。
