Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
Sci China Life Sci. 2019 Oct;62(10):1332-1367. doi: 10.1007/s11427-019-9587-y. Epub 2019 Aug 22.
Natural products (NPs), including traditional Chinese medicine (TCM), have been long and widely used in the prevention and treatment of central nervous system (CNS) diseases by virtue of their abundant sources, diverse structures, and novel activities. In this review article, we intend to summarize and discuss the situation or status of the clinical employments or trials of the NPs and their derivatives with CNS activities. NPs that have been extensively studied in preclinical research in recent years are also included. The compounds presented in this review are classified according to their indications and followed by details such as natural sources, possible biological mechanisms, and development status, while a considerable proportion of them are found in TCM. In addition, some drug combinations with synergistic effects are also mentioned. According to their impressive therapeutic effects and novel chemical structures, NPs are not only effective therapeutic remedies in clinic, but also lead compounds for structural modification, which indicate that nature brings new avenues to the therapy of CNS diseases.
天然产物（NPs），包括中药（TCM），由于其丰富的来源、多样的结构和新颖的活性，长期以来一直被广泛用于预防和治疗中枢神经系统（CNS）疾病。在这篇综述文章中，我们旨在总结和讨论具有 CNS 活性的 NPs 及其衍生物的临床应用或试验情况或现状。近年来在临床前研究中广泛研究的 NPs 也包括在内。本文综述中呈现的化合物根据其适应症进行分类，并详细说明其天然来源、可能的生物学机制和开发状况，其中相当一部分存在于中药中。此外，还提到了一些具有协同作用的药物组合。由于它们具有令人印象深刻的治疗效果和新颖的化学结构，NPs 不仅是临床有效的治疗药物，也是结构修饰的先导化合物，这表明自然界为 CNS 疾病的治疗带来了新的途径。
