Stevens Christine, Ton Erinn, Jones Prentiss, Shattuck Brandy
Western Michigan University Homer Stryker M.D. School of Medicine, 276 Portage Street #200, Kalamazoo, MI, 49007, USA.
Forensic Sci Med Pathol. 2019 Dec;15(4):598-602. doi: 10.1007/s12024-019-00143-0. Epub 2019 Aug 23.
In this report, a pediatric case of bowel obstruction with sepsis complicated by methamphetamine toxicity is described. The decedent, an eleven-year-old female with a clinical history of pica, was found unresponsive in her home and pronounced dead following unsuccessful resuscitative efforts. Radiologic imaging showed multiple radio-opaque foreign objects in the stomach and bowel. Autopsy revealed a green leafy substance, coins and other metallic items, folded paper, and plastic in her stomach and bowels. Postmortem iliac blood and urine tested positive for amphetamine and methamphetamine. While the decedent's medical history and autopsy findings provided evidence consistent with bowel obstruction with sepsis due to the ingestion of foreign materials, the high methamphetamine concentration was suggestive of concurrent methamphetamine toxicity. Unique complications associated with this case include the phenomenon that methamphetamine toxicity and bowel obstruction can present similarly in children and the reported opinion that accidental drug ingestion is uncommon in children over the age of five. This case emphasizes that the age range for suspected accidental drug ingestion should be expanded for those with pica, as these patients, despite being older, may not be able to differentiate between what they should and should not ingest. Furthermore, when treating a pediatric patient with pica that appears to present with bowel obstruction, unintentional drug ingestion should also be considered, particularly if there is a suspicion that the child lives in a household where drugs are abused, given the prospect that drug toxicity can present similarly.
在本报告中,描述了一例患有肠梗阻并伴有败血症且并发甲基苯丙胺中毒的儿科病例。死者是一名11岁女性,有异食癖病史,在家中被发现无反应,经抢救无效后被宣布死亡。放射影像学检查显示胃和肠道内有多个不透射线的异物。尸检发现其胃和肠道内有绿叶物质、硬币及其他金属物品、折叠的纸张和塑料。死后髂骨血液和尿液的苯丙胺和甲基苯丙胺检测呈阳性。虽然死者的病史和尸检结果提供了因摄入异物导致肠梗阻并伴有败血症的证据,但高浓度的甲基苯丙胺提示存在并发的甲基苯丙胺中毒。与该病例相关的独特并发症包括甲基苯丙胺中毒和肠梗阻在儿童中可能表现相似的现象,以及报道称五岁以上儿童意外药物摄入并不常见的观点。该病例强调,对于有异食癖的患者,应扩大疑似意外药物摄入的年龄范围,因为这些患者尽管年龄较大,但可能无法区分应摄入和不应摄入的东西。此外,在治疗疑似患有肠梗阻的有异食癖的儿科患者时,也应考虑无意的药物摄入,特别是如果怀疑该儿童生活在有药物滥用情况的家庭中,因为药物中毒可能表现相似。