Center of Inorganic Chemistry (CEQUINOR, CONICET-CICPBA-UNLP)-Department of Chemistry-Faculty of Exact Sciences, National University of La Plata, Boulevard 120 e/60 y 64, 1900, B1900AVV, La Plata, Argentina.
Biol Trace Elem Res. 2020 Jun;195(2):725-731. doi: 10.1007/s12011-019-01874-5. Epub 2019 Aug 24.
Peroxidovanadium(V) and oxidovanadium(IV) compounds have been tested as peroxidase-similar compounds. Their catalytic performance was tested on phenol red and pyrogallol substrates. Bromination kinetic studies revealed Michaelis-Menten behavior with respect to phenol red for both complexes. Catalytic efficiency is ~ 10 M min. Both vanadium complexes showed the capacity to oxidize pyrogallol, but only the oxidovanadium (IV) complex follows Michaelis-Menten kinetics with respect to this substrate (K = 1.05 × 10 M). Peroxidovanadium(V) complex displayed a more complex mechanism, and further studies became necessary to elucidate it. The structure-activity relationship was also assessed.
过钒(V)和氧钒(IV)化合物已被测试为过氧化物酶类似物。它们的催化性能在苯酚红和焦儿茶酚底物上进行了测试。溴化动力学研究表明，这两种配合物对苯酚红均表现出米氏-门坦行为。催化效率约为 10 M min。两种钒配合物都显示出氧化焦儿茶酚的能力，但只有氧钒(IV)配合物对该底物表现出米氏-门坦动力学（K = 1.05 × 10 M）。过钒(V)配合物表现出更复杂的机制，需要进一步研究来阐明。还评估了结构-活性关系。
