诺氟沙星和氟罗沙星在鼠伤寒沙门氏菌和大肠杆菌所致实验性感染中的比较活性。

Comparative activities of norfloxacin and fleroxacin in experimental infections due to Salmonella typhimurium and Escherichia coli.

作者信息

Hof H, Fabrig J

机构信息

Institute of Hygiene and Microbiology, University of Würzburg, West Germany.

出版信息

J Antimicrob Chemother. 1988 Oct;22 Suppl D:123-7. doi: 10.1093/jac/22.supplement_d.123.

DOI:10.1093/jac/22.supplement_d.123

PMID:3144530

Abstract

Norfloxacin and fleroxacin displayed similar in-vitro activity against test strains of Escherichia coli (MIC 0.06 mg/l) and Salmonella typhimurium (0.125 mg/l). Septicaemic infection of mice with E. coli could be almost cured by quinolones but not by ampicillin. Fleroxacin was more potent than norfloxacin. Infection of mice with S. typhimurium was much more difficult to treat. In spite of higher doses the bacterial counts remained at a considerable level. Again, fleroxacin was more active in vivo than norfloxacin.

摘要

诺氟沙星和氟罗沙星对大肠杆菌（MIC 0.06毫克/升）和鼠伤寒沙门氏菌（0.125毫克/升）测试菌株显示出相似的体外活性。喹诺酮类药物可几乎治愈小鼠的大肠杆菌败血症感染，但氨苄西林则不能。氟罗沙星比诺氟沙星更有效。用鼠伤寒沙门氏菌感染小鼠则更难治疗。尽管使用了更高剂量，细菌数量仍维持在相当高的水平。同样，氟罗沙星在体内比诺氟沙星更具活性。