Autonomous University of the State of Mexico (UAEMex), Faculty of Medicine, Toluca, 50180, Mexico.
University of Duisburg-Essen, University Hospital Essen, Institute of Medical Psychology and Behavioral Immunobiology, Essen 45122, Germany.
Auton Neurosci. 2019 Nov;221:102577. doi: 10.1016/j.autneu.2019.102577. Epub 2019 Jul 16.
The present study aimed to compare linear and symbolic dynamics (SD) indices for detecting the autonomic cardiac changes produced by endotoxemia in freely-moving rats. In this context, we analyzed ECG-derived R-R time series in freely moving Dark Agouti rats, which received lipopolysaccharide (LPS, n = 9), or vehicle (V, n = 7). Five minutes R-R time series were assessed every hour up to +12 h and + 24 h post-LPS injection. We found that SD indices showed significant differences at +7 h between V vs. LPS groups and at +9 h between basal levels of LPS (-3 h) and post-LPS injection (pre-LPS vs. post-LPS). In general, SD seems more appropriate than linear indices to evaluate the autonomic changes of endotoxemic rats. Overall, the symbolic parameters detected decreased R-R variability and complexity, which indicate a modification of the autonomic regulation during LPS-induced endotoxemia. This modification is probably related to a reduced activity of the cholinergic anti-inflammatory pathway at the long term.
本研究旨在比较线性和符号动力学（SD）指标，以检测内毒素血症引起的自由活动大鼠自主心脏变化。在此背景下，我们分析了接受脂多糖（LPS，n=9）或载体（V，n=7）的暗褐家鼠 ECG 衍生的 R-R 时间序列。在 LPS 注射后+12 小时和+24 小时，每小时评估 5 分钟的 R-R 时间序列。我们发现，在 LPS 组与 V 组之间，在+7 小时时 SD 指数存在显著差异，在 LPS 组的基础水平（-3 小时）与 LPS 注射后（pre-LPS 与 post-LPS）之间，在+9 小时时也存在显著差异。总的来说，SD 似乎比线性指数更适合评估内毒素血症大鼠的自主变化。总体而言，符号参数检测到 R-R 变异性和复杂性降低，这表明 LPS 诱导的内毒素血症期间自主调节发生了变化。这种变化可能与长期胆碱能抗炎途径活性降低有关。
