Georgopoulos A, Breyer S, Georgopoulos M, Mailer H, Graninger W
Department of Chemotherapy, University of Vienna.
J Antimicrob Chemother. 1988 Oct;22 Suppl D:25-9. doi: 10.1093/jac/22.supplement_d.25.
Fleroxacin is a new synthetic fluorinated quinolone antimicrobial agent. The in-vitro activity of fleroxacin and five comparative quinolones against 541 clinical isolates was studied. Minimum inhibitory concentrations (MIC90) of fleroxacin were less than or equal to 2.0 mg/l for Enterobacteriaceae, less than or equal to 8.0 mg/l for Pseudomonas aeruginosa and 1.0 mg/l for Acinetobacter calcoaceficis and 8 mg/l for streptococci. The activity of fleroxacin was comparable with that of ofloxacin, pefloxacin and norfloxacin, but less than that of ciprofloxacin. All quinolones showed little difference between MIC and minimum bactericidal concentrations (MBCs).
氟罗沙星是一种新型合成的氟化喹诺酮类抗菌剂。研究了氟罗沙星和五种对照喹诺酮类药物对541株临床分离菌的体外活性。对于肠杆菌科细菌，氟罗沙星的最低抑菌浓度（MIC90）小于或等于2.0mg/L；对于铜绿假单胞菌，小于或等于8.0mg/L；对于醋酸钙不动杆菌，为1.0mg/L；对于链球菌，为8mg/L。氟罗沙星的活性与氧氟沙星、培氟沙星和诺氟沙星相当，但低于环丙沙星。所有喹诺酮类药物的MIC和最低杀菌浓度（MBC）之间差异不大。
