氟罗沙星对卡他莫拉菌的杀菌活性速率与阿莫西林-克拉维酸的比较。

Rate of bactericidal activity for Branhamella catarrhalis of fleroxacin compared with that of amoxycillin-clavulanic acid.

作者信息

Yourassowsky E, Van der Linden M P, Lismont M J, Crokaert F, Glupczynski Y

机构信息

Department of Microbiology, Brugmann University Hospital, Brussels, Belgium.

出版信息

J Antimicrob Chemother. 1988 Oct;22 Suppl D:43-7. doi: 10.1093/jac/22.supplement_d.43.

DOI:10.1093/jac/22.supplement_d.43

PMID:3144548

Abstract

The rate of bactericidal activity of fleroxacin was compared with that of the combination of amoxycillin and clavulanic acid (in the proportion of 4 to 1) on beta-lactamase producing strains of Branhamella catarrhalis. The rate of bactericidal activity of 1 mg/l was as rapid as that of 1 mg/l of amoxycillin-clavulanic acid combination. This rate was not significantly more rapid if the concentrations of fleroxacin were increased to 10 mg/l. In conclusion, the bactericidal activity of fleroxacin is at least as good as that of the combination of amoxycillin and clavulanic acid. Fleroxacin showed a bactericidal effect for B. catarrhalis at concentrations that would be achieved in humans.

摘要

将氟罗沙星的杀菌活性速率与阿莫西林和克拉维酸（比例为4比1）的组合对产β-内酰胺酶的卡他莫拉菌菌株的杀菌活性速率进行了比较。1毫克/升氟罗沙星的杀菌活性速率与1毫克/升阿莫西林-克拉维酸组合的杀菌活性速率一样快。如果将氟罗沙星的浓度增加到10毫克/升，该速率并不会显著加快。总之，氟罗沙星的杀菌活性至少与阿莫西林和克拉维酸的组合一样好。氟罗沙星在人体可达到的浓度下对卡他莫拉菌显示出杀菌作用。