Golomb G
Department of Pharmacy, School of Pharmacy, Hebrew University of Jerusalem, Israel.
J Biomater Appl. 1987 Oct;2(2):266-89. doi: 10.1177/088532828700200205.
Calcification is the most frequent cause of the failure of bioprosthetic heart valves fabricated from glutaraldehyde pretreated porcine aortic valves or bovine pericardium. Formulation and evaluation of controlled-release drug delivery system to inhibit bioprosthetic heart valve calcification is reviewed.