Sager G, Trovik T, Slørdal L, Jaeger R, Prytz P S, Brox J, Reikerås O
Department of Pharmacology, University of Tromsø, Norway.
Scand J Clin Lab Invest. 1988 Sep;48(5):419-24. doi: 10.1080/00365518809085751.
The present study was undertaken to decide whether the bound fractions and/or total concentrations of catecholamines were determinative for the variability of biologically active concentrations in human plasma. The binding and concentrations of noradrenaline (NA) and adrenalin (Adr) were determined in acute phase plasma after major hip surgery in five subjects. The bound fractions before surgery were 23.0% and 18.4% for NA and Adr, respectively. The binding of catecholamines increased in the post-operative period. Five days after surgery the binding of NA and Adr was 30.9% and 24.0%, respectively. The surgical trauma induced an acute phase reaction in plasma with a decrease of albumin (HSA) concentrations whereas the concentrations of alpha-1 acid glycoprotein (AAG) increased. The catecholamine concentrations showed a considerable inter- and intraindividual variability. However, the present work shows that the variability of the biologically active catecholamine concentrations is mainly dependent on the total plasma concentrations and not the plasma protein binding.
本研究旨在确定儿茶酚胺的结合部分和/或总浓度是否决定人血浆中生物活性浓度的变异性。测定了5名受试者在大髋关节手术后急性期血浆中去甲肾上腺素（NA）和肾上腺素（Adr）的结合情况及浓度。术前NA和Adr的结合部分分别为23.0%和18.4%。术后儿茶酚胺的结合增加。术后5天，NA和Adr的结合分别为30.9%和24.0%。手术创伤引起血浆急性期反应，白蛋白（HSA）浓度降低，而α-1酸性糖蛋白（AAG）浓度升高。儿茶酚胺浓度显示出相当大的个体间和个体内变异性。然而，目前的研究表明，生物活性儿茶酚胺浓度的变异性主要取决于血浆总浓度，而非血浆蛋白结合情况。
