Liang Wen Quan, Hou Yu, Zhao Cun You
Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Department of Pediatric Neurology, Affiliated BaYi Children's Hospital, PLA Army General Hospital, Beijing 100700, China.
Yi Chuan. 2019 Aug 20;41(8):677-685. doi: 10.16288/j.yczz.19-126.
MicroRNAs (miRNAs) compose a class of non-coding transcripts with a mean length of 22 nucleotides, and play critical roles in regulating gene expression in the process of development, proliferation and differentiation of neurons. Recent genome-wide association studies (GWAS) find most of schizophrenia-associated single nucleotide polymorphisms (SNPs) locating in the non-coding regions, providing functional implications of miRNAs in the development of schizophrenia. In this review, we highlight the interplays between GWAS-SNPs and miRNAs in four perspectives: SNP in miRNA gene; miRNA located in the host gene; SNP located in the miRNA's seed sequence; SNP located in the miRNA's binding site. We also speculate on the future research on the role of miRNA in the development of schizophrenia.
微小RNA（miRNA）是一类平均长度为22个核苷酸的非编码转录本，在神经元发育、增殖和分化过程中调节基因表达方面发挥着关键作用。最近的全基因组关联研究（GWAS）发现，大多数与精神分裂症相关的单核苷酸多态性（SNP）位于非编码区，这提示了miRNA在精神分裂症发生发展中的功能意义。在本综述中，我们从四个角度重点阐述了GWAS-SNP与miRNA之间的相互作用：miRNA基因中的SNP；位于宿主基因中的miRNA；位于miRNA种子序列中的SNP；位于miRNA结合位点的SNP。我们还对miRNA在精神分裂症发生发展中作用的未来研究进行了推测。
