[喀麦隆食管癌的预后与生存：一项预后研究]
[Prognosis and survival of esophageal cancer in Cameroon: a prognostic study].
作者信息
Nga Winnie Tatiana Bekolo, Eloumou Servais Albert Fiacre Bagnaka, Engbang Jean Paul Ndamba, Bell Esther Mbassi Dina, Mayeh Anne Marthe Maison, Atenguena Etienne, Biwole Martin Essomba, Ayissi Georges Barthélémy Nko'o, Kenfack Gabin, Noah Dominique Noah, Luma Henry Namme, Sone Albert Mouelle, Ndom Paul, Ndam Elie Claude Ndjitoyap
机构信息
Service de Médecine Interne de l'Hôpital Général de Douala, Douala, Cameroun.
Faculté de Médecine et de Sciences Pharmaceutiques de Douala, Douala, Cameroun.
出版信息
Pan Afr Med J. 2019 May 31;33:73. doi: 10.11604/pamj.2019.33.73.16112. eCollection 2019.
INTRODUCTION
Esophageal cancer is rare. Poor prognosis is due to delayed diagnosis. Five year survival is less than 20%. This study aimed to investigate the factors associated with survival of patients with esophageal cancer in Cameroon.
METHODS
We conducted a prognostic study in the General Hospitals in Yaoundé and in Douala over a period of 11 years from 1 January 2005 to 31 December 2015. The parameters studied were those associated with survival. Survival was established on the basis of the date of diagnosis and of the date of death or of the last visit. SPSS software (Statistical Package for Social Sciences) version 23 allowed for data analysis. Kaplan Meier curve was used to estimate the survival function. Log RankTest allowed for comparison among the different groups. Cox regression helped to highlight the different factors associated with it. Significance level was set at 0.05.
RESULTS
We collected data from 49 medical records. The average age of patients was 57.83 years. There was a male predominance (71.4%; n=35) with a sex ratio of 2.49. The follow-up period was 3.2 months. Median survival was 6.67 months (CI 95% [1.33-10.4]) and the average survival time was 7.99 months (CI 95% [4.42-11.17]). Multivariate-adjusted analysis showed that stage IV was a predictive factor of mortality (HR = 2.79; CI95% [1.13-6.89], p = 0.025]).
CONCLUSION
Esophageal cancer is a rare disease with poor prognosis. Prognostic factor is the tumor stage.
引言
食管癌较为罕见。预后不良归因于诊断延迟。五年生存率低于20%。本研究旨在调查喀麦隆食管癌患者生存的相关因素。
方法
我们于2005年1月1日至2015年12月31日期间在雅温得和杜阿拉的综合医院进行了一项预后研究。所研究的参数为与生存相关的参数。根据诊断日期、死亡日期或最后一次就诊日期确定生存情况。使用SPSS软件（社会科学统计软件包）23版进行数据分析。采用Kaplan Meier曲线估计生存函数。Log Rank检验用于不同组之间的比较。Cox回归有助于突出与之相关的不同因素。显著性水平设定为0.05。
结果
我们收集了49份病历的数据。患者的平均年龄为57.83岁。男性占主导（71.4%；n = 35），性别比为2.49。随访期为3.2个月。中位生存期为6.67个月（95%置信区间[1.33 - 10.4]），平均生存时间为7.99个月（95%置信区间[4.42 - 11.17]）。多变量调整分析显示，IV期是死亡的预测因素（风险比 = 2.79；95%置信区间[1.13 - 6.89]，p = 0.025）。
结论
食管癌是一种预后不良的罕见疾病。预后因素是肿瘤分期。
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