Nhiem Nguyen Xuan, Thinh Ngo Sy, Thu Nguyen Thi Bich, Anh Luu The, Minh Ngoc Tran, Tai Bui Huu, Yen Pham Hai, Kiem Phan Van, Van Minh Chau, Park Seonju, Kim Seung Hyun
Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Cau Giay, Vietnam.
National Institute of Medicinal Materials, Hoan Kiem, Vietnam.
Biosci Biotechnol Biochem. 2019 Dec;83(12):2177-2182. doi: 10.1080/09168451.2019.1654848. Epub 2019 Aug 25.
Three new flavonol glycosides, fissflavosides A-C (1-3), together with six known flavonol glycosides, kaempferol 3--L-rhamnopyranosyl-(1→2)--D-galactopyranoside (4), kaempferol 3--L-rhamnopyranosyl-(1→6)--D-galactopyranoside (5), kaempferol 3--L-rhamnopyranosyl-(1→6)--D-glucopyranoside (6), rhamnetin 3--L-rhamnopyranosyl-(1→2)--D-glucopyranoside (7), rutin (8), and isorhamnetin 3--L-rhamnopyranosyl-(1→2)--D-galactopyranoside (9) were isolated from the methanol extract of the leaves. Their chemical structures were determined by 1D-, 2D-NMR, and MS data as well as in comparison with reported data in the literature. Compounds 1-9 showed weak cytotoxic activity on three human cancer cell lines, HT-29, A-2058, A-549 with IC ranging from 134.6 to 162.6 µM. In addition, the antioxidant capacities of compounds were also tested by ORAC assay. All compounds showed significant antioxidant with trolox equivalents ranging from 4.4 to 8.6 µM at the concentration of 1.0 µM. The results indicated 7 and 8 having meaningful reducing capacity of copper (I) ions of 2.7 to 6.9 µM at the concentrations of 1 and 2 µM.
