Lampé L G, Vojcek L, Princzkel E, Csömör S
Department of Obstetrics and Gynaecology, University Medical School of Debrecen, Hungary.
Acta Physiol Hung. 1988;71(4):529-34.
Circulatory responses to hypoxaemia were studied in 16 foetal lambs in 120-129 and 135-145 days of gestation (term: 147 days). Under general anaesthesia catheters were inserted into the foetal vessels and the umbilical blood was measured during antipyrine infusion by the Fick steady-state diffusion method. The combined ventricular output and actual organ blood flows were calculated from injections of radionuclide-labelled microspheres into a forelimb and a hindlimb vein. Isocapnic hypoxia was produced by giving the ewe a breathing gas mixture of 9% O2 and 3% CO2 in N2 for 30 min. A significant increase was found in the blood flow of the myocardium, the lungs, the brain and in the combined ventricular output between 0.80 and 0.95 gestation times. Under isocapnic hypoxaemia blood flow increased to the brain, heart and adrenals, whilst it decreased to the lungs, kidneys, gut and carcass. The observed changes were different at the two measurement times. Under hypoxia, depending on the gestation time, the blood flow increased in the diencephalon, midbrain, hypophysis and in the cervical cord. In the cerebral, cerebellar and lumbosacral cord it remained unchanged, while decreasing in the chorioid plexus and in the hippocampus. In the gestation period under examination the foetal circulation undergoes significant redistribution.
对16只妊娠120 - 129天和135 - 145天（足月为147天）的胎羊进行了低氧血症的循环反应研究。在全身麻醉下，将导管插入胎羊血管，并通过菲克稳态扩散法在注入安替比林期间测量脐血。通过将放射性核素标记的微球注入前肢和后肢静脉来计算联合心室输出量和实际器官血流量。通过给母羊提供含9% O₂、3% CO₂和N₂的混合呼吸气体30分钟来产生等碳酸血症性低氧。发现在妊娠0.80至0.95倍时，心肌、肺、脑的血流量以及联合心室输出量显著增加。在等碳酸血症性低氧血症下，脑、心脏和肾上腺的血流量增加，而肺、肾、肠道和躯体的血流量减少。在两个测量时间观察到的变化不同。在低氧情况下，根据妊娠时间，间脑、中脑、垂体和颈髓的血流量增加。在大脑、小脑和腰骶髓中血流量保持不变，而脉络丛和海马体中的血流量减少。在所检查的妊娠期内，胎儿循环会发生显著的重新分布。
