Crown O O, Ogundele O O, Akinmoladun A C, Famusiwa C D, Josiah S S, Olaleye M T, Akindahunsi A A
The Federal University of Technology Akure.
Niger J Physiol Sci. 2019 Jun 30;34(1):1-10.
Nephrotoxicity, with the attendant risk of progression to kidney failure, is a growing problem in many parts of the world. Current orthodox treatment options for nephrotoxicity and kidney failure are limited and there is need for alternative or complementary approaches. This study aimed at evaluating the effect of three structurally related flavonoids, catechin, quercetin and taxifolin on renal redox and metabolite biochemical disturbances in rotenone intoxicated animals. Male Wistar rats were administered 1.5 mg/kg rotenone (s.c.) for ten days followed by post-treatment with catechin (5, 10 or 20 mg/kg), quercetin (5, 10, or 20 mg/kg) and taxifolin (0.25, 0.5 or 1.0 mg/kg) (s.c.), for 3 days. Renal redox indices and levels of renal-related metabolites (creatinine, urea and uric acid) were assessed after sacrifice of animals. Catechin, quercetin and taxifolin significantly attenuated rotenone-induced effects on oxidative stress markers and metabolites linked to renal health. Quercetin was clearly more effective than catechin. The activity demonstrated by taxifolin, despite being administered at the lowest doses, was compelling. The results highlight the potential of these phytochemicals in the management of renal dysfunction. The findings additionally suggest a correlation between the structure of the flavonoids and their activity but also indicate that additional structural considerations beyond conventionally acknowledged ones may be involved.
肾毒性以及随之而来的发展为肾衰竭的风险，在世界许多地区正成为一个日益严重的问题。目前针对肾毒性和肾衰竭的传统治疗选择有限，因此需要替代或补充方法。本研究旨在评估三种结构相关的黄酮类化合物（儿茶素、槲皮素和花旗松素）对鱼藤酮中毒动物肾脏氧化还原和代谢物生化紊乱的影响。雄性Wistar大鼠连续十天皮下注射1.5mg/kg鱼藤酮，随后分别皮下注射儿茶素（5、10或20mg/kg）、槲皮素（5、10或20mg/kg）和花旗松素（0.25、0.5或1.0mg/kg），持续3天。处死动物后评估肾脏氧化还原指标和与肾脏相关的代谢物（肌酐、尿素和尿酸）水平。儿茶素、槲皮素和花旗松素显著减轻了鱼藤酮对与肾脏健康相关的氧化应激标志物和代谢物的影响。槲皮素明显比儿茶素更有效。尽管花旗松素的给药剂量最低，但其表现出的活性令人信服。结果突出了这些植物化学物质在管理肾功能障碍方面的潜力。研究结果还表明黄酮类化合物的结构与其活性之间存在相关性，但也表明可能涉及传统认知之外的其他结构因素。
