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虎样蕈样肉芽肿:蕈样肉芽肿一种罕见变异型的不寻常临床表现。

Tiger-like mycosis fungoides: an unusual clinical presentation of a rare variant of mycosis fungoides.

作者信息

Ahmad Anam, Semkova Kristina, Stefanato Catherine M, Calonje Eduardo J, Choczaj-Kukula Anna, Palamaras Ioulios

机构信息

Department of Dermatology Royal Free NHS Foundation Trust, London.

出版信息

Dermatol Online J. 2019 Jul 15;25(7):13030/qt0w1035f7.

Abstract

Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma. Mycosis fungoides classically presents in the skin as patches, plaques, tumors, or erythroderma, progressing to involve the lymph nodes and peripheral blood. The many clinical variants, with different histologic patterns, and the subtle early clinical and histologic changes may delay early diagnosis and present a diagnostic challenge for clinicians. The greatest challenge in diagnosis is the pre-mycotic stage, which may closely resemble eczematous or psoriasiform dermatitis clinically and histologically. The persistence of lesions and inadequate response to treatment are the first warning signs. Later stages of MF have a poor prognosis with poor therapeutic response and fatal outcome. We describe a 72-year-old man, who presented with a two-year history of an unusual eruption, which started on the abdomen, around the waistline, and gradually spread to involve his back, trunk, and buttocks. Clinically, the skin eruption presented as tiger-like stripes. The diagnosis was confirmed after histopathologic examination. The patient was treated with NB-UVB phototherapy with marked improvement.

摘要

蕈样肉芽肿(MF)是最常见的皮肤T细胞淋巴瘤类型。蕈样肉芽肿典型地在皮肤表现为斑片、斑块、肿瘤或红皮病,进而累及淋巴结和外周血。其众多具有不同组织学模式的临床变体,以及早期细微的临床和组织学变化可能会延迟早期诊断,并给临床医生带来诊断挑战。诊断中最大的挑战是蕈样前期,其在临床和组织学上可能与湿疹样或银屑病样皮炎极为相似。皮损持续存在且对治疗反应不佳是最初的警示信号。MF的后期预后较差,治疗反应不佳且结局致命。我们描述一名72岁男性,他有两年不寻常皮疹病史,皮疹始于腹部、腰围周围,逐渐蔓延至背部、躯干和臀部。临床上,皮疹表现为虎纹状。经组织病理学检查确诊。患者接受窄谱中波紫外线(NB-UVB)光疗后有明显改善。

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Mycosis fungoides: classic disease and variant presentations.蕈样肉芽肿:经典疾病及变异型表现
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