Grose Elysia, Ramien Michele
Faculty of Medicine, University of Ottawa, Ottawa, Ontario.
Dermatol Online J. 2019 Jul 15;25(7):13030/qt1gs433hj.
Interstitial granulomatous drug reaction is a rare condition presenting as erythematous-to-violaceous plaques on the lateral trunk, axillae, buttocks, and thighs. Calcium-channel blockers, angiotensin converting enzyme inhibitors, beta-blockers, and statins have been described as drugs that can trigger interstitial granulomatous drug reaction. We present a case of interstitial granulomatous drug reaction related to hydrochlorothiazide and our approach to management of this condition. The diagnosis was confirmed with a skin biopsy and a rechallenge of hydrochlorothiazide, which exacerbated the patient's symptoms. The patient improved significantly with rigorous photoprotection, combination dapsone-alitretinoin therapy, and discontinuation of hydrochlorothiazide.
间质性肉芽肿性药物反应是一种罕见病症，表现为躯干外侧、腋窝、臀部和大腿出现从红斑到紫蓝色的斑块。钙通道阻滞剂、血管紧张素转换酶抑制剂、β受体阻滞剂和他汀类药物已被描述为可引发间质性肉芽肿性药物反应的药物。我们报告一例与氢氯噻嗪相关的间质性肉芽肿性药物反应病例以及我们对该病症的处理方法。通过皮肤活检和氢氯噻嗪再激发试验确诊，该试验使患者症状加重。通过严格的光防护、氨苯砜 - 阿利维A酸联合治疗以及停用氢氯噻嗪，患者症状明显改善。
