着色性干皮病细胞对癌基因转化的敏感性。
Susceptibility of Xeroderma pigmentosum cells to transformation with oncogenes.
作者信息
Suarez H, Daya-Grosjean L, Varlet I, Sarasin A
机构信息
Institut de Recherches Scientifiques sur le Cancer, Villejuif, France.
出版信息
Biochimie. 1988 Jul;70(7):969-73. doi: 10.1016/0300-9084(88)90239-8.
Oncogenes capable of transforming 3T3-Vill cells were not detected in 'normal' Xeroderma pigmentosum (XP) fibroblasts but were detected in two out of six XP epitheliomas. Preliminary results concerning the transfection of 'normal' XP fibroblasts with activated ras genes seem to indicate that these cells are as resistant as the healthy controls to the transforming action of the group II oncogenes. However, after transfection with v-myb oncogene in XP fibroblasts several cellular clones have been isolated showing some new phenotypic characteristics.
在“正常”的着色性干皮病（XP）成纤维细胞中未检测到能够转化3T3-Vill细胞的癌基因，但在六个XP上皮瘤中有两个检测到了此类癌基因。关于用活化的ras基因转染“正常”XP成纤维细胞的初步结果似乎表明，这些细胞与健康对照一样，对II类癌基因的转化作用具有抗性。然而，在XP成纤维细胞中用v-myb癌基因转染后，已分离出几个细胞克隆，它们表现出一些新的表型特征。
Zotero 插件