Hanna S, Diana F, Slevinski J, Veronich K, Lachman L
J Pharm Sci. 1978 Dec;67(12):1723-5. doi: 10.1002/jps.2600671224.
Polarographic investigation of clorazepate monopotassium and dipotassium showed two cathodic waves at about -1.28 and -1.66 v. The cathodic wave associated with clorazepate monopotassium or dipotassium at about -1.66 v was a pH-independent, diffusion-controlled wave. This wave was used to develop a specific stability-indicating procedure for clorazepate monopotassium and dipotassium in the presence of their degradation products, namely, nordiazepam, 2-amino-5-chlorobenzophenone, and glycine. The method involves a 10(-2) M LiOH-10(-1) M LiCl extraction of the active ingredient from the formulation, filtration, dilution with the same supporting electrolyte, and then use of the standard addition technique for drug quantitation in capsules. Typical fomulation excipients did not interfere with the analysis. Accuracy and precision of the procedure were 99.55 +/- 0.68%.
氯氮卓一钾和二钾的极谱研究显示在约-1.28伏和-1.66伏处有两个阴极波。与氯氮卓一钾或二钾相关的约-1.66伏处的阴极波是一个与pH无关的扩散控制波。该波被用于开发一种在存在其降解产物即去甲西泮、2-氨基-5-氯二苯甲酮和甘氨酸的情况下测定氯氮卓一钾和二钾的特定稳定性指示方法。该方法包括用10⁻² M氢氧化锂-10⁻¹ M氯化锂从制剂中萃取活性成分，过滤，用相同的支持电解质稀释，然后使用标准加入技术对胶囊中的药物进行定量。典型的制剂辅料不干扰分析。该方法的准确度和精密度为99.55±0.68%。
