Centre d'Etude et Traitement de la Douleur, Hopital Ambroise-Pare, Boulogne-Billancourt, France.
U987, INSERM, Boulogne Billancourt, France.
RMD Open. 2019 Aug 6;5(2):e001029. doi: 10.1136/rmdopen-2019-001029. eCollection 2019.
An endemic increase in the number of deaths attributable to prescribed opioids is found in all developed countries. In 2016 in the USA, more than 46 people died each day from overdoses involving prescription opioids. European data show that the number of patients receiving strong opioids is increasing. In addition, there is an upsurge in hospitalisations for opioid intoxication, opioid abuse and deaths in some European countries. This class of analgesic is increasingly used in many rheumatological pathologies. Cohort studies, in various chronic non-cancer pain (CNCP) (osteoarthritis, chronic low back pain, rheumatoid arthritis, etc), show that between 2% and 8% of patients are treated with strong opioids. In order to help rheumatologists prescribe strong opioids under optimal conditions and to prevent the risk of death, abuse and misuse, recommendations have recently been published (in France in 2016, the recommendations of the French Society of Study and Treatment of Pain, in 2017, the European recommendations of the European Federation of IASP Chapters and the American Society of International Pain Physicians). They agree on the same general principles: opioids may be of interest in situations of CNCP, but their prescription must follow essential rules. It is necessary to make an accurate assessment of the pain and its origin, to formulate therapeutic objectives (pain, function and/or quality of life), to evaluate beforehand the risk of abuse and to get a specialised opinion beyond a certain dose or duration of prescription.
在所有发达国家,因处方类阿片而导致的死亡人数都呈地方性增长。2016 年,美国每天有超过 46 人死于涉及处方类阿片的过量用药。欧洲的数据表明,使用强阿片类药物的患者数量正在增加。此外,一些欧洲国家因阿片类药物中毒、滥用和死亡而住院的人数也在上升。这类镇痛药在许多风湿性疾病中越来越多地被使用。在各种慢性非癌性疼痛(CNCP)(骨关节炎、慢性腰痛、类风湿关节炎等)的队列研究中,2%至 8%的患者接受强阿片类药物治疗。为了帮助风湿病医生在最佳条件下开具强阿片类药物,并预防死亡、滥用和误用的风险,最近发布了一些建议(2016 年法国发布了法国疼痛研究和治疗学会的建议,2017 年欧洲国际疼痛研究协会章节和美国国际疼痛医师协会发布了欧洲建议)。这些建议都同意以下相同的一般原则:在 CNCP 情况下,阿片类药物可能是有用的,但它们的处方必须遵循必要的规则。有必要准确评估疼痛及其来源,制定治疗目标(疼痛、功能和/或生活质量),预先评估滥用风险,并在一定剂量或处方持续时间后寻求专业意见。