肾上腺素在大鼠结肠腺癌中的非典型血管效应及硝酸甘油增强光动力反应的现象：肾上腺素能和一氧化氮能机制及新应用方面
Phenomenon of atypical vascular effects of epinephrine and an increase of photodynamic response by nitroglycerin in rats with colon adenocarcinoma: adrenergic and nitrergic mechanisms and novel applied aspects.
作者信息
Agranovich Ilana, Borisova Ekaterina, Navolokin Nikita, Bucharskaya Alla, Maslyakova Galina, Shirokov Alexander, Abdurashitov Arkady, Angelov Ivan, Khorovodov Alexander, Terskov Andrey, Mamedova Aysel, Klimova Maria, Semyachkina-Glushkovskaya Oxana
机构信息
Saratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia.
Institute of Electronics, Bulgarian Academy of Sciences, Tsarigradsko Chaussee Blvd. 72, Sofia 1784, Bulgaria.
出版信息
Biomed Opt Express. 2019 Jul 18;10(8):4115-4125. doi: 10.1364/BOE.10.004115. eCollection 2019 Aug 1.
Abstract
Using an original model of stress-induced colon adenocarcinoma, we uncover atypical vasorelaxation effects of a mucosa injection of epinephrine assessed by laser speckle contrast imaging and a significant increase of fluorescent intensity of 5-ALA/PpIX from malignant colon tissues by a mucosa injection of nitroglycerine. We clearly demonstrate a high activity of adrenergic and nitrergic mechanisms underlying this phenomenon and discuss their application in improving of optical approaches for effective diagnosis of gastrointestinal cancer.
摘要
利用应激诱导的结肠癌原始模型，我们通过激光散斑对比成像揭示了黏膜注射肾上腺素的非典型血管舒张作用，以及黏膜注射硝酸甘油后恶性结肠组织中5-氨基乙酰丙酸/原卟啉IX荧光强度的显著增加。我们清楚地证明了这一现象背后肾上腺素能和一氧化氮能机制的高活性，并讨论了它们在改进胃肠道癌有效诊断光学方法中的应用。
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