对具有抗惊厥活性的活性化合物进行植物化学分析。 （注：原文“L.”表述不完整，可能影响准确理解，这里按字面翻译了）
Phytochemical analysis of L. active compounds possessing anticonvulsant activity.
作者信息
Raafat K, Wurglics M
机构信息
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Beirut Arab University, 115020 Beirut, Lebanon.
Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt/Main, Germany.
出版信息
J Tradit Complement Med. 2018 Sep 28;9(4):263-270. doi: 10.1016/j.jtcme.2018.01.007. eCollection 2019 Oct.
The anticonvulsant potential of methanol-extract (Fc) has been studied. It was found that Fc most active fraction is rich in oligosaccharides (OFG). H, C NMR and Nano-ESI, MALDI MS, and LC-MS techniques proved that OFG contains alpha-glucopyranoside oligomer in high amounts. Both Fc and OFG reduced strychnine (STR) convulsion-action. Fc and OFG fully protected the experimental-animals from STR-lethality. The intracerebroventricular-administration (ICV) of Fc or OFG in combination with glycine in ethanol-treated mice caused a dose-dependent returning to a 2nd-loss of righting-reflex (LORR), and was antagonized by STR. FC and OFG ICV injection counteracted STR-inhibition, confirming that Fc/OFG anticonvulsant mechanism of action was mediated by potentiation of glycine receptor. These results support Fc and OFG potential anticonvulsant-activity with good safety-profile.
已对甲醇提取物（Fc）的抗惊厥潜力进行了研究。发现Fc的最活跃部分富含低聚糖（OFG）。氢谱、碳谱核磁共振以及纳升电喷雾电离、基质辅助激光解吸电离质谱和液相色谱-质谱技术证明，OFG含有大量的α-吡喃葡萄糖苷低聚物。Fc和OFG均降低了士的宁（STR）的惊厥作用。Fc和OFG使实验动物完全免受STR致死。在乙醇处理的小鼠中，将Fc或OFG与甘氨酸联合进行脑室内给药（ICV）会导致剂量依赖性地恢复第二次翻正反射消失（LORR），并被STR拮抗。Fc和OFG脑室内注射可抵消STR抑制作用，证实Fc/OFG的抗惊厥作用机制是通过增强甘氨酸受体介导的。这些结果支持Fc和OFG具有潜在的抗惊厥活性且安全性良好。
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