促血管生成基因中有害变异的亲本来源对先天性心脏病患者胎儿生长的影响：数据与分析
Effect of parental origin of damaging variants in pro-angiogenic genes on fetal growth in patients with congenital heart defects: Data and analyses.
作者信息
Russell Mark W, Moldenhauer Julie S, Rychik Jack, Burnham Nancy B, Zullo Erin, Parry Samuel I, Simmons Rebecca A, Elovitz Michal A, Nicolson Susan C, Linn Rebecca L, Johnson Mark P, Yu Sunkyung, Sampson Matthew G, Hakonarson Hakon, Gaynor J William
机构信息
Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.
Center for Fetal Diagnosis and Therapy, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
出版信息
Data Brief. 2019 Jul 26;25:104311. doi: 10.1016/j.dib.2019.104311. eCollection 2019 Aug.
The placenta is a highly vascular structure composed of both maternal and fetal elements. We have determined that damaging variants in genes responsible for the positive regulation of angiogenesis (PRA) (GO:0045766) that are inherited by the fetus impair fetal growth and placental function in pregnancies involving critical congenital cardiac defects (Russell et al., 2019). In this dataset, we present the specific genetic variants identified, describe the parental origin of each variant where possible and present the analyses regarding the potential effects of parental origin of the variant on placental function and fetal growth. The data presented are related to the research article "Damaging variants in pro-angiogenic genes impair growth in fetuses with cardiac defects" (Russell et al., 2019).
胎盘是一种高度血管化的结构，由母体和胎儿成分组成。我们已经确定，胎儿遗传的负责血管生成正调控（PRA）（GO:0045766）的基因中的有害变异会损害患有严重先天性心脏缺陷的妊娠中的胎儿生长和胎盘功能（Russell等人，2019年）。在这个数据集中，我们展示了鉴定出的特定基因变异，尽可能描述每个变异的亲本来源，并展示关于变异亲本来源对胎盘功能和胎儿生长的潜在影响的分析。所呈现的数据与研究文章《促血管生成基因中的有害变异损害患有心脏缺陷胎儿的生长》（Russell等人，2019年）相关。
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