Toll样受体8（TLR8）物种特异性下游差异调节基因（DEGs）的数据。
The data of TLR8 species specific downstream differentially regulated genes (DEGs).
作者信息
Ao Da, Zhu Jianzhong
机构信息
Comparative Medicine Research Institute, Yangzhou University, China.
College Veterinary Medicine, Yangzhou University, China.
出版信息
Data Brief. 2019 Aug 2;25:104314. doi: 10.1016/j.dib.2019.104314. eCollection 2019 Aug.
To compare porcine TLR8 (pTLR8) and human TLR8 (hTLR8) signaling pathways and downstream genes, we activated the pTLR8 and hTLR8 reporter cells with TLR8 agonist R848, and subjected the stimulated cells together with non-stimulated control cells for transcriptome analysis. There are 1157 differentially expression genes (DEGs) in R848 activated hTLR8 cells, whereas 502 DEGs in R848 activated pTLR8 cells. Among these DEGs, 804 genes are hTLR8 specific, 149 genes are pTLR8 specific, and 353 genes are hTLR8 and pTLR8 common. Related Results were published in reference [Ao, 2019].
为了比较猪TLR8（pTLR8）和人TLR8（hTLR8）信号通路及下游基因，我们用TLR8激动剂R848激活pTLR8和hTLR8报告细胞，并将刺激后的细胞与未刺激的对照细胞一起进行转录组分析。R848激活的hTLR8细胞中有1157个差异表达基因（DEG），而R848激活的pTLR8细胞中有502个DEG。在这些DEG中，804个基因是hTLR8特有的，149个基因是pTLR8特有的，353个基因是hTLR8和pTLR8共有的。相关结果发表于参考文献[Ao，2019]。
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