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[Synergistic activity of isepamicin and beta-lactam antibiotics against Pseudomonas aeruginosa in vitro and in vivo].

作者信息

Shiritani Y, Yamaji S, Aoki A, Saigusa M, Yokoiyama S, Gato S, Tsuji A

机构信息

Research Laboratories, Toyo Jozo Co., Ltd.

出版信息

Jpn J Antibiot. 1988 Nov;41(11):1591-9.

PMID:3145343
Abstract

Synergistic activities of isepamicin (ISP) and a beta-lactam antibiotic such as piperacillin (PIPC) or cefotaxime (CTX) against Pseudomonas aeruginosa were demonstrated in vitro and in vivo. In vitro synergistic activity was observed when ISP was used together PIPC or CTX. The synergy observed in vitro was reproduced in vivo against experimental mouse infections, and a ISP-PIPC or a ISP-CTX combination showed significantly greater protective effects than individual antibiotics by themselves.

摘要

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