Nur Hakan, Tuncer Tiraje
Department of Physical Medicine and Rehabilitation, Medicine Faculty of Akdeniz University, Antalya, Turkey.
Turk J Phys Med Rehabil. 2018 Mar 3;64(2):121-125. doi: 10.5606/tftrd.2018.1496. eCollection 2018 Jun.
The aim of this study was to examine the relationship between the body composition measures and knee osteoarthritis (OA) in postmenopausal women to determine whether the fat mass or the lean mass was closely associated with knee OA.
This retrospective, cross-sectional study included a total of 212 postmenopausal women (mean age 59.9±6.2 years; range, 46 to 76 years). Descriptive characteristics were recorded and height was measured using a stadiometer. Body weight, fat mass, and lean mass were estimated using bioelectrical impedance analysis. X-rays of the knees were obtained. Knee OA was radiographically diagnosed according to the Kellgren-Lawrence criteria. Based on the radiographic knee OA diagnosis the women were divided into two groups. Logistic regression analyses were used to examine the associations between the body composition measures and knee OA.
Knee OA was present in 117 women. Body Mass Index, body weight, fat mass, and lean mass were all significantly associated with knee OA after adjusting for confounding factors such as age, height, and physical activity (p<0.001). When assessed together with lean mass in a multivariate regression model, fat mass was closely and significantly found to be related to knee OA, compared to lean mass (p<0.001, OR: 1.17). Furthermore the fat mass/lean mass ratio was positively associated with knee OA (p<0.001).
In postmenopausal women body weight was significantly and positively associated with knee OA and among the components that constitute body weight, fat mass was closely and significantly associated with knee OA compared to lean mass. This result suggests that the relationship between obesity and knee OA is mainly based on the fat mass, and supports the importance of systemic metabolic effects of adiposity in this relationship.
本研究旨在探讨绝经后女性身体成分测量指标与膝关节骨关节炎（OA）之间的关系，以确定脂肪量或瘦体重是否与膝关节OA密切相关。
这项回顾性横断面研究共纳入212名绝经后女性（平均年龄59.9±6.2岁；范围46至76岁）。记录描述性特征，使用身高计测量身高。采用生物电阻抗分析法估算体重、脂肪量和瘦体重。获取膝关节X线片。根据Kellgren-Lawrence标准对膝关节OA进行影像学诊断。根据膝关节OA的影像学诊断将女性分为两组。采用逻辑回归分析来检验身体成分测量指标与膝关节OA之间的关联。
117名女性存在膝关节OA。在调整年龄、身高和身体活动等混杂因素后，体重指数、体重、脂肪量和瘦体重均与膝关节OA显著相关（p<0.001）。在多变量回归模型中与瘦体重一起评估时，发现脂肪量与膝关节OA密切且显著相关，相比之下瘦体重与膝关节OA的相关性较弱（p<0.001，OR：1.17）。此外，脂肪量/瘦体重比值与膝关节OA呈正相关（p<0.001）。
在绝经后女性中，体重与膝关节OA显著正相关，在构成体重的各成分中，与瘦体重相比，脂肪量与膝关节OA密切且显著相关。这一结果表明肥胖与膝关节OA之间的关系主要基于脂肪量，并支持了肥胖在这种关系中的全身代谢效应的重要性。
