在一名被诊断为轴性脊柱关节炎的患者中，使用戈利木单抗治疗时出现复发性葡萄膜炎：这是一种矛盾效应吗？
Recurrent uveitis under golimumab treatment in a patient diagnosed with axial spondyloarthritis: Is it a paradoxical effect?
作者信息
Mengi Alper, Özdolap Şenay, Oray Hande, Sarıkaya Selda
机构信息
Department of Physical Medicine and Rehabilitation, Gaziosmanpaşa Taksim Training and Research Hospital, Istanbul, Turkey.
Department of Physical Medicine and Rehabilitation, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey.
出版信息
Turk J Phys Med Rehabil. 2019 Feb 6;65(2):191-193. doi: 10.5606/tftrd.2019.2596. eCollection 2019 Jun.
Abstract
Anti-tumor necrosis factor drugs are highly effective in the treatment of spondyloarthropathies. In recent years, there have been reports of paradoxical effects with the use of these drugs. Herein, we report the first case of axial spondyloarthropathy in whom recurrent attacks of panuveitis paradoxically developed under golimumab treatment in the light of literature data.
摘要
抗肿瘤坏死因子药物在治疗脊柱关节病方面非常有效。近年来，有使用这些药物产生矛盾效应的报道。在此，根据文献数据，我们报告首例在使用戈利木单抗治疗期间出现全葡萄膜炎反复发作为矛盾表现的轴性脊柱关节病病例。
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Recurrent uveitis under golimumab treatment in a patient diagnosed with axial spondyloarthritis: Is it a paradoxical effect?在一名被诊断为轴性脊柱关节炎的患者中，使用戈利木单抗治疗时出现复发性葡萄膜炎：这是一种矛盾效应吗？
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本文引用的文献
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Paradoxical reactions under TNF-α blocking agents and other biological agents given for chronic immune-mediated diseases: an analytical and comprehensive overview.用于慢性免疫介导疾病的肿瘤坏死因子-α阻断剂及其他生物制剂下的反常反应：分析性与综合性概述
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Treatment of seronegative spondyloarthropathy-associated uveitis with golimumab: retrospective case series.戈利木单抗治疗血清阴性脊柱关节病相关性葡萄膜炎：回顾性病例系列
Clin Exp Ophthalmol. 2014 May-Jun;42(4):392-5. doi: 10.1111/ceo.12207. Epub 2013 Oct 23.
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New onset of uveitis during anti-tumor necrosis factor treatment for rheumatic diseases.风湿性疾病的抗肿瘤坏死因子治疗期间新出现的葡萄膜炎。
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Golimumab: A novel human anti-TNF-alpha monoclonal antibody for the treatment of rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis.戈利木单抗：一种用于治疗类风湿关节炎、强直性脊柱炎和银屑病关节炎的新型人抗肿瘤坏死因子-α单克隆抗体。
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