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使用胰岛素泵间歇性输注特立帕肽治疗难治性甲状旁腺功能减退症:一例报告

Alternative treatment of resistant hypoparathyroidism by intermittent infusion of teriparatide using an insulin pump: A case report.

作者信息

Pekkolay Zafer, Kılınç Faruk, Soylu Hikmet, Balsak Belma, Güven Mehmet, Altun Tuzcu Şadiye, Kara Ali Veysel, Tuzcu Alpaslan Kemal

机构信息

Department of Internal Medicine, Dicle University School of Medicine, Diyarbakır, Turkey.

Department of Adult Endocrinology, Fırat University School of Medicine, Elazığ, Turkey.

出版信息

Turk J Phys Med Rehabil. 2019 May 2;65(2):198-201. doi: 10.5606/tftrd.2019.2718. eCollection 2019 Jun.

Abstract

Hypoparathyroidism usually responds to oral active vitamin D and calcium, but, although rare, some patients do not respond to this treatment. A 47-year-old Caucasian female presented to our medical unit with classical oral treatment-resistant hypocalcemia after thyroidectomy. Teriparatide was infused through the insulin pump with dosage set to 1 unit which equals to 2.5 μg of teriparatide. In conclusion, intermittent subcutaneous infusion of teriparatide using an insulin pump is a safe and effective treatment modality to ensure normocalcemic conditions in patients with classical treatment-resistant hypoparathyroidism. 39th Turkey Congress of Endocrinology and Metabolic Diseases, May 3-7, 2017, Antalya, Turkey.

摘要

甲状旁腺功能减退通常对口服活性维生素D和钙剂有反应,但尽管罕见,仍有一些患者对这种治疗无反应。一名47岁的白种女性在甲状腺切除术后因典型的口服治疗抵抗性低钙血症入住我院。特立帕肽通过胰岛素泵输注,剂量设定为1单位,相当于2.5μg特立帕肽。总之,使用胰岛素泵间歇性皮下输注特立帕肽是一种安全有效的治疗方式,可确保经典治疗抵抗性甲状旁腺功能减退患者血钙正常。2017年5月3 - 7日,第39届土耳其内分泌与代谢疾病大会,土耳其安塔利亚

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