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1
Polypharmacy with perampanel for drug-resistant, focal non-convulsive status epilepticus as a manifestation of a stroke-like episode in MELAS.使用吡仑帕奈多药联合治疗耐药性局灶性非惊厥性癫痫持续状态，其为线粒体脑肌病伴乳酸血症和卒中样发作（MELAS）中卒中样发作的一种表现。
Epilepsy Behav Rep. 2019 Jun 24;12:100327. doi: 10.1016/j.ebr.2019.100327. eCollection 2019.
2
Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome.吡仑帕奈：一种用于治疗与线粒体脑肌病伴乳酸血症和卒中样发作（MELAS）综合征相关的难治性癫痫持续状态的替代疗法。
Epilepsy Behav Case Rep. 2019 Feb 7;11:92-95. doi: 10.1016/j.ebcr.2019.01.008. eCollection 2019.
3
Mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS) may respond to adjunctive ketogenic diet.伴乳酸性酸中毒和卒中样发作的线粒体脑病（MELAS）可能对辅助生酮饮食有反应。
Pediatr Neurol. 2014 May;50(5):498-502. doi: 10.1016/j.pediatrneurol.2014.01.009. Epub 2014 Jan 7.
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Perampanel in patients with refractory and super-refractory status epilepticus in a neurological intensive care unit.在神经重症监护病房中，吡仑帕奈用于治疗难治性和超难治性癫痫持续状态患者。
Epilepsy Behav. 2015 Aug;49:354-8. doi: 10.1016/j.yebeh.2015.04.005. Epub 2015 May 9.
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Bálint-like syndrome as an unusual representation of non-convulsive status epilepticus.Bálint 样综合征作为一种非惊厥性癫痫持续状态的不常见表现。
Epileptic Disord. 2012 Mar;14(1):80-4. doi: 10.1684/epd.2012.0492.
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Cerebral blood flow and oxygen metabolism before and after a stroke-like episode in patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS).线粒体肌病、脑病、乳酸性酸中毒和卒中样发作（MELAS）患者卒中样发作前后的脑血流量和氧代谢
J Neurol Sci. 1998 Jun 11;158(1):58-64. doi: 10.1016/s0022-510x(98)00105-1.
7
Functional outcome after convulsive status epilepticus.癫痫持续状态后的功能结局。
Crit Care Med. 2010 Dec;38(12):2295-303. doi: 10.1097/CCM.0b013e3181f859a6.
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Perampanel in the treatment of focal and idiopathic generalized epilepsies and of status epilepticus.吡仑帕奈用于治疗局灶性癫痫、特发性全身性癫痫及癫痫持续状态。
Expert Rev Clin Pharmacol. 2015;8(6):733-40. doi: 10.1586/17512433.2015.1091303. Epub 2015 Oct 5.
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[Usefulness of L-arginine infusion for status epilepticus in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes].
No To Hattatsu. 2007 Jan;39(1):38-43.
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Focal and Generalized Patterns of Cerebral Cortical Veins Due to Non-Convulsive Status Epilepticus or Prolonged Seizure Episode after Convulsive Status Epilepticus - A MRI Study Using Susceptibility Weighted Imaging.非惊厥性癫痫持续状态或惊厥性癫痫持续状态后长时间癫痫发作所致大脑皮质静脉的局灶性和全身性模式——一项使用磁敏感加权成像的MRI研究
PLoS One. 2016 Aug 3;11(8):e0160495. doi: 10.1371/journal.pone.0160495. eCollection 2016.

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Ionotropic Glutamate Receptors in Epilepsy: A Review Focusing on AMPA and NMDA Receptors.离子型谷氨酸受体与癫痫：聚焦 AMPA 和 NMDA 受体的综述。
Biomolecules. 2020 Mar 18;10(3):464. doi: 10.3390/biom10030464.

本文引用的文献

1
Clinical profiles associated with serum perampanel concentrations in children with refractory epilepsy.与难治性癫痫儿童血清吡仑帕奈浓度相关的临床特征。
Epilepsy Behav. 2019 May;94:82-86. doi: 10.1016/j.yebeh.2019.02.004. Epub 2019 Mar 18.
2
Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome.吡仑帕奈：一种用于治疗与线粒体脑肌病伴乳酸血症和卒中样发作（MELAS）综合征相关的难治性癫痫持续状态的替代疗法。
Epilepsy Behav Case Rep. 2019 Feb 7;11:92-95. doi: 10.1016/j.ebcr.2019.01.008. eCollection 2019.
3
8-year retrospective analysis of intravenous arginine therapy for acute metabolic strokes in pediatric mitochondrial disease.8 年回顾性分析静脉内精氨酸治疗儿科线粒体疾病急性代谢性中风。
Mol Genet Metab. 2018 Mar;123(3):301-308. doi: 10.1016/j.ymgme.2018.01.010. Epub 2018 Feb 2.
4
Mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS) may respond to adjunctive ketogenic diet.伴乳酸性酸中毒和卒中样发作的线粒体脑病（MELAS）可能对辅助生酮饮食有反应。
Pediatr Neurol. 2014 May;50(5):498-502. doi: 10.1016/j.pediatrneurol.2014.01.009. Epub 2014 Jan 7.

Polypharmacy with perampanel for drug-resistant, focal non-convulsive status epilepticus as a manifestation of a stroke-like episode in MELAS.

作者信息

Finsterer Josef

机构信息

Krankenanstalt Rudolfstiftung, Vienna, Austria.

出版信息

Epilepsy Behav Rep. 2019 Jun 24;12:100327. doi: 10.1016/j.ebr.2019.100327. eCollection 2019.

DOI:10.1016/j.ebr.2019.100327
PMID:31453566
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6657535/
Abstract
摘要